Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease.

Product information

CAS Number: 2434633-17-5

Molecular Weight: 462.54

Formula: C29H26N4O2

Chemical Name: 5-[8-({[1,1'-biphenyl]-4-yl}methoxy)-2-methylimidazo[1,2-a]pyridin-3-yl]-N-ethylpyridine-2-carboxamide

Smiles: CC1N=C2C(=CC=CN2C=1C1=CN=C(C=C1)C(=O)NCC)OCC1=CC=C(C=C1)C1=CC=CC=C1

InChiKey: VNNXRQLFCKSSMH-UHFFFAOYSA-N

InChi: InChI=1S/C29H26N4O2/c1-3-30-29(34)25-16-15-24(18-31-25)27-20(2)32-28-26(10-7-17-33(27)28)35-19-21-11-13-23(14-12-21)22-8-5-4-6-9-22/h4-18H,3,19H2,1-2H3,(H,30,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Aβ42-IN-1 free base treatment shows that the CLint value is 84.7 µL/min/mg protein.

Products are for research use only. Not for human use.